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At the same time, acquired resistance is not taken into account, as a result, for example, tetracyclines, which in the first years of use were active against most clinically significant microorganisms rx online pharm canada, have now lost a significant part of their activity spectrum precisely because of the development of acquired resistance in pneumococci, staphylococci, gonokokkov, enterobacteria. III generation cephalosporins are usually considered as drugs with a wide spectrum of activity, but they do not act on MRSA, many anaerobes, enterococci, listeria, atypical pathogens, etc.